papers
Published papers and reports from the TaBriX Team
Discovery of uncompetitive inhibitors of SapM that compromise intracellular survival of Mycobacterium tuberculosis.
Fernández-Soto P, Casulli J, Solano-Castro D, Rodríguez-Fernández P, Jowitt TA, Travis MA, Cavet JS, Tabernero L.Sci Rep. 2021 Apr 7;11(1):7667. doi: 10.1038/s41598-021-87117-x.PMID: 33828158
Mechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs.
Fernandez-Soto P, Bruce AJE, Fielding AJ, Cavet JS, Tabernero L.Sci Rep. 2019 Jul 16;9(1):10315. doi: 10.1038/s41598-019-46731-6.PMID: 31312014
Structure-Based Design of MptpB Inhibitors That Reduce Multidrug-Resistant Mycobacterium tuberculosis Survival and Infection Burden in Vivo.
Vickers CF, Silva APG, Chakraborty A, Fernandez P, Kurepina N, Saville C, Naranjo Y, Pons M, Schnettger LS, Gutierrez MG, Park S, Kreiswith BN, Perlin DS, Thomas EJ, Cavet JS, Tabernero L.J Med Chem. 2018 Sep 27;61(18):8337-8352. doi: 10.1021/acs.jmedchem.8b00832. Epub 2018 Sep 10.PMID: 30153005
Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.
Böhmer F, Szedlacsek S, Tabernero L, Ostman A, den Hertog J.FEBS J. 2013 Jan;280(2):413-31. doi: 10.1111/j.1742-4658.2012.08655.x. Epub 2012 Jul 2.PMID: 22682070
New strategies in fighting TB: targeting Mycobacterium tuberculosis-secreted phosphatases MptpA & MptpB.
Silva AP, Tabernero L.Future Med Chem. 2010 Aug;2(8):1325-37. doi: 10.4155/fmc.10.214.PMID: 21426021
A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis.
Beresford NJ, Saville C, Bennett HJ, Roberts IS, Tabernero L.BMC Genomics. 2010 Aug 2;11:457. doi: 10.1186/1471-2164-11-457.PMID: 20678187
Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages.
Beresford NJ, Mulhearn D, Szczepankiewicz B, Liu G, Johnson ME, Fordham-Skelton A, Abad-Zapatero C, Cavet JS, Tabernero L.J Antimicrob Chemother. 2009 May;63(5):928-36. doi: 10.1093/jac/dkp031. Epub 2009 Feb 24.
MptpB, a virulence factor from Mycobacterium tuberculosis, exhibits triple-specificity phosphatase activity.
Beresford N, Patel S, Armstrong J, Szöor B, Fordham-Skelton AP, Tabernero L.Biochem J. 2007 Aug 15;406(1):13-8. doi: 10.1042/BJ20070670.PMID: 17584180